| EC |
3.5.4.32 |
| Accepted name: |
8-oxoguanine deaminase |
| Reaction: |
8-oxoguanine + H2O = urate + NH3 |
| Glossary: |
8-oxoguanine = 2-amino-7,9-dihydro-1H-purine-6,8-dione |
| Other name(s): |
8-OGD |
| Systematic name: |
8-oxoguanine aminohydrolase |
| Comments: |
Zn2+ is bound in the active site. 8-Oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions.
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| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Hall, R.S., Fedorov, A.A., Marti-Arbona, R., Fedorov, E.V., Kolb, P., Sauder, J.M., Burley, S.K., Shoichet, B.K., Almo, S.C. and Raushel, F.M. The hunt for 8-oxoguanine deaminase. J. Am. Chem. Soc. 132 (2010) 1762–1763. [DOI] [PMID: 20088583] |
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| [EC 3.5.4.32 created 2012] |
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