ExplorEnz: EC 3.5.4.34

Your query returned 1 entry. Printable version

3.5.4.34

Accepted name:

tRNA^Ala(adenine³⁷) deaminase

Reaction:

adenine³⁷ in tRNA^Ala + H₂O = hypoxanthine³⁷ in tRNA^Ala + NH₃

Other name(s):

ADAT1; Tad1p

Systematic name:

tRNA^Ala(adenine³⁷) aminohydrolase

Comments:

The enzyme deaminates adenosine³⁷ to inosine in eukaryotic tRNA^Ala [1]. tRNA editing is strictly dependent on Mg²⁺ [2].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Maas, S., Gerber, A.P. and Rich, A. Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. Proc. Natl. Acad. Sci. USA 96 (1999) 8895–8900. [DOI] [PMID: 10430867]
2.	Gerber, A., Grosjean, H., Melcher, T. and Keller, W. Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2. EMBO J. 17 (1998) 4780–4789. [DOI] [PMID: 9707437]
3.	Keegan, L.P., Gerber, A.P., Brindle, J., Leemans, R., Gallo, A., Keller, W. and O'Connell, M.A. The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification. Mol. Cell Biol. 20 (2000) 825–833. [DOI] [PMID: 10629039]

[EC 3.5.4.34 created 2013]