| EC |
3.5.4.39 |
| Accepted name: |
GTP cyclohydrolase IV |
| Reaction: |
GTP + H2O = 7,8-dihydroneopterin 2′,3′-cyclic phosphate + formate + diphosphate |
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For diagram of methanopterin biosynthesis (part 1), click here |
| Glossary: |
7,8-dihydroneopterin 2′,3′-cyclic phosphate = 2-amino-6-{(S)-hydroxy[(4R)-2-hydroxy-2-oxido-1,3,2-dioxaphospholan-4-yl]methyl}-7,8-dihydropteridin-4(1H)-one = 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-4(1H)-pteridinone 1,2-cyclic phosphate
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| Other name(s): |
MptA; GTP cyclohydrolase MptA |
| Systematic name: |
GTP 7,8-8,9-dihydrolase (cyclizing, formate-releasing, diphosphate-releasing) |
| Comments: |
Requires Fe2+. A zinc protein. The enzyme is involved in methanopterin biosynthesis in methanogenic archaea. cf. GTP cyclohydrolase I (EC 3.5.4.16), GTP cyclohydrolase II (EC 3.5.4.25) and GTP cyclohydrolase IIa (EC 3.5.4.29). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Grochowski, L.L., Xu, H., Leung, K. and White, R.H. Characterization of an Fe2+-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii. Biochemistry 46 (2007) 6658–6667. [DOI] [PMID: 17497938] |
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| [EC 3.5.4.39 created 2013] |
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