| EC |
3.5.4.4 |
| Accepted name: |
adenosine deaminase |
| Reaction: |
(1) adenosine + H2O = inosine + NH3
(2) 2′-deoxyadenosine + H2O = 2′-deoxyinosine + NH3 |
| Other name(s): |
deoxyadenosine deaminase |
| Systematic name: |
adenosine aminohydrolase |
| Comments: |
The enzyme, found in a wide variety of microorganisms, plants, invertebrates, and animals, plays a role in purine metabolism. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9026-93-1 |
| References: |
| 1. |
Kaplan, N.O., Colowick, S.P. and Ciotti, M.M. Enzymatic deamination of cytosine nucleosides. J. Biol. Chem. 194 (1952) 579–591. [PMID: 14927650] |
| 2. |
Powell, J.F. and Hunter, J.R. Adenosine deaminase and ribosidase in spores of Bacillus cereus. Biochem. J. 62 (1956) 381–387. [PMID: 13303984] |
| 3. |
Singh, L.S. and Sharma, R. Purification and characterization of intestinal adenosine deaminase from mice. Mol. Cell. Biochem. 204 (2000) 127–134. [DOI] [PMID: 10718633] |
| 4. |
Cristalli, G., Costanzi, S., Lambertucci, C., Lupidi, G., Vittori, S., Volpini, R. and Camaioni, E. Adenosine deaminase: functional implications and different classes of inhibitors. Med. Res. Rev. 21 (2001) 105–128. [DOI] [PMID: 11223861] |
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| [EC 3.5.4.4 created 1961] |
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