| EC |
3.5.4.5 |
| Accepted name: |
cytidine deaminase |
| Reaction: |
(1) cytidine + H2O = uridine + NH3
(2) 2′-deoxycytidine + H2O = 2′-deoxyuridine + NH3 |
| Other name(s): |
cytosine nucleoside deaminase; (deoxy)cytidine deaminase; cdd (gene name); CDA (gene name) |
| Systematic name: |
cytidine/2′-deoxycytidine aminohydrolase |
| Comments: |
Contains zinc. Catalyses the deamination of cytidine and 2′-deoxycytidine with similar efficiencies. The enzyme, which is widely distributed among organisms, is involved in salvage of both exogenous and endogenous cytidine and 2′-deoxycytidine for UMP synthesis. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9025-06-3 |
| References: |
| 1. |
Roberts, D.W.A. The wheat leaf phosphatases. II. Pathway of hydrolysis of some nucleotides at pH 5.5. J. Biol. Chem. 222 (1956) 259–270. [PMID: 13366999] |
| 2. |
Wang, T.P., Sable, H.Z. and Lampen, J.O. Enzymatic deamination of cytosine nucleosides. J. Biol. Chem. 184 (1950) 17–28. [PMID: 15421968] |
| 3. |
Song, B.H. and Neuhard, J. Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase. Mol. Gen. Genet. 216 (1989) 462–468. [PMID: 2526291] |
| 4. |
Laliberte, J. and Momparler, R.L. Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA. Cancer Res. 54 (1994) 5401–5407. [PMID: 7923172] |
| 5. |
Vincenzetti, S., Cambi, A., Neuhard, J., Schnorr, K., Grelloni, M. and Vita, A. Cloning, expression, and purification of cytidine deaminase from Arabidopsis thaliana. Protein Expr. Purif. 15 (1999) 8–15. [DOI] [PMID: 10024464] |
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| [EC 3.5.4.5 created 1961, modified 2013] |
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