| EC |
3.5.4.9 |
| Accepted name: |
methenyltetrahydrofolate cyclohydrolase |
| Reaction: |
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate |
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For diagram of folate cofactors, click here and for diagram of C1 metabolism, click here |
| Other name(s): |
Citrovorum factor cyclodehydrase; cyclohydrolase; formyl-methenyl-methylenetetrahydrofolate synthetase (combined); 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing) |
| Systematic name: |
5,10-methenyltetrahydrofolate 5-hydrolase (ring-opening) |
| Comments: |
In eukaryotes, the enzyme occurs as a trifunctional enzyme that also has methylenetetrahydrofolate dehydrogenase (NADP+) (EC 1.5.1.5) and formate—tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes, it occurs as a bifunctional enzyme that also has dehydrogenase (EC 1.5.1.5) activity or formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9027-97-8 |
| References: |
| 1. |
Rabinowitz, J.C. and Pricer, W.E. The enzymatic synthesis of N10-formyltetrahydrofolic acid and its role in ATP formation during formiminoglycine degradation. J. Am. Chem. Soc. 78 (1956) 4176–4178. |
| 2. |
Tabor, H. and Wyngarden, L. The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid. J. Biol. Chem. 234 (1959) 1830–1849. [PMID: 13672973] |
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| [EC 3.5.4.9 created 1961] |
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