ExplorEnz: EC 3.5.99.10

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3.5.99.10

Accepted name:

2-iminobutanoate/2-iminopropanoate deaminase

Reaction:

(1) 2-iminobutanoate + H₂O = 2-oxobutanoate + NH₃
(2) 2-iminopropanoate + H₂O = pyruvate + NH₃

Other name(s):

yjgF (gene name); ridA (gene name); enamine/imine deaminase (ambiguous)

Systematic name:

2-iminobutanoate aminohydrolase

Comments:

This enzyme, which has been found in all species and tissues examined, catalyses the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5′-phosphate-dependent dehydratases, such as EC 4.3.1.19, threonine ammonia-lyase and EC 4.3.1.17, L-serine ammonia-lyase. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Lambrecht, J.A., Flynn, J.M. and Downs, D.M. Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5′-phosphate (PLP)-dependent enzyme reactions. J. Biol. Chem. 287 (2012) 3454–3461. [DOI] [PMID: 22094463]

[EC 3.5.99.10 created 2014]