The Enzyme Database

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Accepted name: 2-iminobutanoate/2-iminopropanoate deaminase
Reaction: (1) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3
(2) 2-iminopropanoate + H2O = pyruvate + NH3
Other name(s): yjgF (gene name); ridA (gene name); enamine/imine deaminase (ambiguous)
Systematic name: 2-iminobutanoate aminohydrolase
Comments: This enzyme, which has been found in all species and tissues examined, catalyses the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5′-phosphate-dependent dehydratases, such as EC, threonine ammonia-lyase and EC, L-serine ammonia-lyase. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Lambrecht, J.A., Flynn, J.M. and Downs, D.M. Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5′-phosphate (PLP)-dependent enzyme reactions. J. Biol. Chem. 287 (2012) 3454–3461. [DOI] [PMID: 22094463]
[EC created 2014]

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