Accepted name: 2-iminobutanoate/2-iminopropanoate deaminase
Reaction: (1) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3
(2) 2-iminopropanoate + H2O = pyruvate + NH3
Other name(s): yjgF (gene name); ridA (gene name); enamine/imine deaminase (ambiguous)
Systematic name: 2-iminobutanoate aminohydrolase
Comments: This enzyme, which has been found in all species and tissues examined, catalyses the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5′-phosphate-dependent dehydratases, such as EC, threonine ammonia-lyase and EC, L-serine ammonia-lyase. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates.
1.  Lambrecht, J.A., Flynn, J.M. and Downs, D.M. Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5′-phosphate (PLP)-dependent enzyme reactions. J. Biol. Chem. 287 (2012) 3454–3461. [PMID: 22094463]
[EC created 2014]