ExplorEnz: EC 3.6.1.12

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3.6.1.12

Accepted name:

dCTP diphosphatase

Reaction:

dCTP + H₂O = dCMP + diphosphate

Other name(s):

DCTPP1 (gene name); deoxycytidine-triphosphatase; dCTPase; dCTP pyrophosphatase; deoxycytidine triphosphatase; deoxy-CTPase

Systematic name:

dCTP nucleotidohydrolase

Comments:

The mammalian enzyme also displays weak activity against dTTP and dATP, but none against dGTP. Activity is highest with analogs including 5-iodo-dCTP and 5-methyl-dCTP.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9024-87-7

References:

1.	Zimmerman, S.B. and Kornberg, A. Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Escherichia coli. J. Biol. Chem. 236 (1961) 1480–1486. [PMID: 13788541]
2.	Moroz, O.V., Murzin, A.G., Makarova, K.S., Koonin, E.V., Wilson, K.S. and Galperin, M.Y. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-α NTP pyrophosphohydrolases with potential "house-cleaning" functions. J. Mol. Biol. 347 (2005) 243–255. [DOI] [PMID: 15740738]
3.	Wu, B., Liu, Y., Zhao, Q., Liao, S., Zhang, J., Bartlam, M., Chen, W. and Rao, Z. Crystal structure of RS21-C₆, involved in nucleoside triphosphate pyrophosphohydrolysis. J. Mol. Biol. 367 (2007) 1405–1412. [DOI] [PMID: 17320107]
4.	Nonaka, M., Tsuchimoto, D., Sakumi, K. and Nakabeppu, Y. Mouse RS21-C₆ is a mammalian 2′-deoxycytidine 5′-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine. FEBS J. 276 (2009) 1654–1666. [DOI] [PMID: 19220460]
5.	Requena, C.E., Perez-Moreno, G., Ruiz-Perez, L.M., Vidal, A.E. and Gonzalez-Pacanowska, D. The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells. Biochem. J. 459 (2014) 171–180. [DOI] [PMID: 24467396]

[EC 3.6.1.12 created 1965]