| EC |
3.6.1.17 |
| Accepted name: |
bis(5′-nucleosyl)-tetraphosphatase (asymmetrical) |
| Reaction: |
P1,P4-bis(5′-guanosyl) tetraphosphate + H2O = GTP + GMP |
| Other name(s): |
bis(5′-guanosyl)-tetraphosphatase; bis(5′-adenosyl)-tetraphosphatase; diguanosinetetraphosphatase (asymmetrical); dinucleosidetetraphosphatase (asymmetrical); diadenosine P1,P4-tetraphosphatase; dinucleoside tetraphosphatase; 1-P,4-P-bis(5′-nucleosyl)-tetraphosphate nucleotidohydrolase |
| Systematic name: |
P1,P4-bis(5′-nucleosyl)-tetraphosphate nucleotidohydrolase |
| Comments: |
Also acts on bis(5′-xanthosyl)-tetraphosphate and, more slowly, on bis(5′-adenosyl)-tetraphosphate and bis(5′-uridyl)-tetraphosphate [cf. EC 3.6.1.41 bis(5′-nucleosyl)-tetraphosphatase (symmetrical)] |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37289-29-5 |
| References: |
| 1. |
Jakubowski, H. and Guranowski, A. Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds. J. Biol. Chem. 258 (1983) 9982–9989. [PMID: 6309793] |
| 2. |
Vallejo, C.M., Lobatón, C.D., Quintanilla, M., Sillero, A. and Sillero, M.A.G. Dinucleosidasetetraphosphatase in rat liver and Artemia salina. Biochim. Biophys. Acta 438 (1976) 304–309. [DOI] [PMID: 181087] |
| 3. |
Warner, A.H. and Finamore, F.J. Isolation, purification, and characterization of P1,P4-diguanosine 5′-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs. Biochemistry 4 (1965) 1568–1575. [PMID: 4955726] |
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| [EC 3.6.1.17 created 1972, modified 1976, modified 1986] |
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