The Enzyme Database

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Accepted name: FAD diphosphatase
Reaction: FAD + H2O = AMP + FMN
For diagram of FAD biosynthesis, click here
Other name(s): FAD pyrophosphatase; riboflavin adenine dinucleotide pyrophosphatase; flavin adenine dinucleotide pyrophosphatase; riboflavine adenine dinucleotide pyrophosphatase; flavine adenine dinucleotide pyrophosphatase
Systematic name: FAD nucleotidohydrolase
Comments: The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme hydrolyses NAD+ and CoA at about half of the rate of hydrolysis of FAD. May be identical with EC nucleotide diphosphatase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37289-30-8
1.  Ravindranath, S.D. and Appaji Rao, N. Nucleotidases in plants. 3. Effect of metabolites on the enzyme hydrolyzing flavine adenine dinucleotide (FAD) from Phaseolus radiatus. Arch. Biochem. Biophys. 133 (1969) 54–59. [DOI] [PMID: 5810832]
2.  Shin, H.J. and Mego, J.L. A rat liver lysosomal membrane flavin-adenine dinucleotide phosphohydrolase: purification and characterization. Arch. Biochem. Biophys. 267 (1988) 95–103. [DOI] [PMID: 2848456]
[EC created 1972]

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