ExplorEnz: EC 3.6.1.27

Your query returned 1 entry. Printable version

3.6.1.27

Accepted name:

undecaprenyl-diphosphate phosphatase

Reaction:

ditrans,octacis-undecaprenyl diphosphate + H₂O = ditrans,octacis-undecaprenyl phosphate + phosphate

For diagram of peptidoglycan biosynthesis (part 3), click here and for diagram of xanthan biosynthesis, click here

Other name(s):

C₅₅-isoprenyl diphosphatase; C₅₅-isoprenyl pyrophosphatase; isoprenyl pyrophosphatase (ambiguous); undecaprenyl pyrophosphate phosphatase; undecaprenyl pyrophosphate pyrophosphatase; UPP phosphatase; Und-PP pyrophosphatase; UppP (ambiguous); BacA; undecaprenyl-diphosphate phosphohydrolase; undecaprenyl-diphosphatase

Systematic name:

ditrans,octacis-undecaprenyl-diphosphate phosphohydrolase

Comments:

Isolated from the bacteria Micrococcus lysodeikticus [1], Escherichia coli [2,3,5,6] and Bacillus subtilis [4]. The product of the reaction, ditrans,octacis-undecaprenyl phosphate, is essential for cell wall polysaccharide biosynthesis in these strains.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9077-80-9

References:

1.	Goldman, R. and Strominger, J.L. Purification and properties of C₅₅-isoprenylpyrophosphate phosphatase from Micrococcus lysodeikticus. J. Biol. Chem. 247 (1972) 5116–5122. [PMID: 4341539]
2.	El Ghachi, M., Bouhss, A., Blanot, D. and Mengin-Lecreulx, D. The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity. J. Biol. Chem. 279 (2004) 30106–30113. [DOI] [PMID: 15138271]
3.	El Ghachi, M., Derbise, A., Bouhss, A. and Mengin-Lecreulx, D. Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli. J. Biol. Chem. 280 (2005) 18689–18695. [DOI] [PMID: 15778224]
4.	Bernard, R., El Ghachi, M., Mengin-Lecreulx, D., Chippaux, M. and Denizot, F. BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance. J. Biol. Chem. 280 (2005) 28852–28857. [DOI] [PMID: 15946938]
5.	Tatar, L.D., Marolda, C.L., Polischuk, A.N., van Leeuwen, D. and Valvano, M.A. An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling. Microbiology 153 (2007) 2518–2529. [DOI] [PMID: 17660416]
6.	Touze, T., Blanot, D. and Mengin-Lecreulx, D. Substrate specificity and membrane topology of Escherichia coli PgpB, an undecaprenyl pyrophosphate phosphatase. J. Biol. Chem. 283 (2008) 16573–16583. [DOI] [PMID: 18411271]

[EC 3.6.1.27 created 1978, modified 2002, modified 2012]