| EC |
3.6.1.31 |
| Accepted name: |
phosphoribosyl-ATP diphosphatase |
| Reaction: |
1-(5-phospho-β-D-ribosyl)-ATP + H2O = 1-(5-phospho-β-D-ribosyl)-AMP + diphosphate |
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For diagram of histidine biosynthesis (early stages), click here |
| Other name(s): |
phosphoribosyl-ATP pyrophosphatase; phosphoribosyladenosine triphosphate pyrophosphatase; 1-(5-phosphoribosyl)-ATP diphosphohydrolase |
| Systematic name: |
1-(5-phospho-β-D-ribosyl)-ATP diphosphohydrolase |
| Comments: |
The Neurospora crassa enzyme also catalyses the reactions of EC 1.1.1.23 (histidinol dehydrogenase) and EC 3.5.4.19 (phosphoribosyl-AMP cyclohydrolase). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 69553-55-5 |
| References: |
| 1. |
Smith, D.W.E. and Ames, B.N. Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis. J. Biol. Chem. 240 (1965) 3056–3063. [PMID: 14342333] |
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| [EC 3.6.1.31 created 1981] |
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