The Enzyme Database

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Accepted name: phosphoribosyl-ATP diphosphatase
Reaction: 1-(5-phospho-β-D-ribosyl)-ATP + H2O = 1-(5-phospho-β-D-ribosyl)-AMP + diphosphate
For diagram of histidine biosynthesis (early stages), click here
Other name(s): phosphoribosyl-ATP pyrophosphatase; phosphoribosyladenosine triphosphate pyrophosphatase; 1-(5-phosphoribosyl)-ATP diphosphohydrolase
Systematic name: 1-(5-phospho-β-D-ribosyl)-ATP diphosphohydrolase
Comments: The Neurospora crassa enzyme also catalyses the reactions of EC (histidinol dehydrogenase) and EC (phosphoribosyl-AMP cyclohydrolase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 69553-55-5
1.  Smith, D.W.E. and Ames, B.N. Phosphoribosyladenosine monophosphate, an intermediate in histidine biosynthesis. J. Biol. Chem. 240 (1965) 3056–3063. [PMID: 14342333]
[EC created 1981]

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