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Your query returned 1 entry. Printable version
EC | 3.6.1.53 | ||||||||
Accepted name: | Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase | ||||||||
Reaction: | (1) CDP-choline + H2O = CMP + phosphocholine (2) ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate |
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Other name(s): | Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase; ADPRibase-Mn | ||||||||
Systematic name: | CDP-choline phosphohydrolase | ||||||||
Comments: | Requires Mn2+. Unlike EC 3.6.1.13, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-β-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose [3]. In rat, the enzyme is found predominantly in thymus and spleen. | ||||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB | ||||||||
References: |
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