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Your query returned 1 entry. Printable version
EC | 3.6.1.60 | ||||
Accepted name: | diadenosine hexaphosphate hydrolase (AMP-forming) | ||||
Reaction: | (1) P1,P6-bis(5′-adenosyl)hexaphosphate + H2O = adenosine 5′-pentaphosphate + AMP (2) P1,P5-bis(5′-adenosyl)pentaphosphate + H2O = adenosine 5′-tetraphosphate + AMP |
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Other name(s): | hAps1; NUDT11 (gene name); hAps2; NUDT10 (gene name) | ||||
Systematic name: | P1,P6-bis(5′-adenosyl)hexaphosphate nucleotidohydrolase (AMP-forming) | ||||
Comments: | A divalent cation is essential for activity. Mn2+ (2–6 mM) is most effective. The enzyme controls intracellular levels of P1,P5-bis(5′-adenosyl)pentaphosphate and P1,P6-bis(5′-adenosyl)hexaphosphate. Weak activity with P1,P4-bis(5′-adenosyl)tetraphosphate. Marked preference for adenine over guanine nucleotides. | ||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB | ||||
References: |
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