| EC |
3.6.5.6 |
| Accepted name: |
tubulin GTPase |
| Reaction: |
GTP + H2O = GDP + phosphate |
| Systematic name: |
GTP phosphohydrolase (microtubule-releasing) |
| Comments: |
An intrinsic activity of α-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Yu, X.C. and Margolin, W. Ca2+-mediated GTP-dependent dynamic assembly of bacetrial cell division protein FtsZ into asters and polymer networks in vitro. EMBO J. 16 (1997) 5455–5463. [DOI] [PMID: 9312004] |
| 2. |
Tian, G., Bhamidipati, A., Cowan, N.J. and Lewis, S.A. Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the α/β-tubulin heterodimer. J. Biol. Chem. 274 (1999) 24054–24058. [DOI] [PMID: 10446175] |
| 3. |
Roychowdhury, S., Panda, D., Wilson, L. and Rasenick, M.M. G protein α subunits activate tubulin GTPase and modulate microtubule polymerization dynamics. J. Biol. Chem. 274 (1999) 13485–13490. [DOI] [PMID: 10224115] |
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| [EC 3.6.5.6 created 2000 as EC 3.6.1.51, transferred 2003 to EC 3.6.5.6] |
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