| EC |
3.7.1.19 |
| Accepted name: |
2,6-dihydroxypseudooxynicotine hydrolase |
| Reaction: |
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O = 2,6-dihydroxypyridine + 4-methylaminobutanoate |
|
For diagram of nicotine catabolism by arthrobacter, click here |
| Glossary: |
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one = 2,6-dihydroxypseudooxynicotine |
| Systematic name: |
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase |
| Comments: |
The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Gherna, R.L., Richardson, S.H. and Rittenberg, S.C. The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine. J. Biol. Chem. 240 (1965) 3669–3674. [PMID: 5835946] |
| 2. |
Sachelaru, P., Schiltz, E., Igloi, G.L. and Brandsch, R. An α/β-fold C—C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans. J. Bacteriol. 187 (2005) 8516–8519. [DOI] [PMID: 16321959] |
|
| [EC 3.7.1.19 created 2012] |
| |
|
| |
|
Printable version