| EC |
3.7.1.2 |
| Accepted name: |
fumarylacetoacetase |
| Reaction: |
4-fumarylacetoacetate + H2O = acetoacetate + fumarate |
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For diagram of tyrosine catabolism, click here |
| Other name(s): |
β-diketonase; fumarylacetoacetate hydrolase |
| Systematic name: |
4-fumarylacetoacetate fumarylhydrolase |
| Comments: |
Also acts on other 3,5- and 2,4-dioxo acids. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9032-59-1 |
| References: |
| 1. |
Connors, W.M. and Stotz, E. The purification and properties of a triacetic acid-hydrolyzing enzyme. J. Biol. Chem. 178 (1949) 881–890. [PMID: 18117010] |
| 2. |
Edwards, S.W. and Knox, W.E. Homogentisate metabolism: the isomerization of maleylacetoacetate by an enzyme which requires glutathione. J. Biol. Chem. 220 (1956) 79–91. [PMID: 13319328] |
| 3. |
Meister, A. and Greenstein, J.P. Enzymatic hydrolysis of 2,4-diketo acids. J. Biol. Chem. 175 (1948) 573–588. [PMID: 18880754] |
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| [EC 3.7.1.2 created 1961] |
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