| EC |
3.7.1.23 |
| Accepted name: |
maleylpyruvate hydrolase |
| Reaction: |
3-maleylpyruvate + H2O = maleate + pyruvate |
| Glossary: |
3-maleylpyruvate = (2Z)-4,6-dioxohept-2-enedioate |
| Other name(s): |
hbzF (gene name) |
| Systematic name: |
(2Z)-4,6-dioxohept-2-enedioate acylhydrolase |
| Comments: |
The enzyme, characterized from the bacterium Pseudomonas alcaligenes NCIMB 9867, catalyses the hydrolysis of 3-maleylpyruvate, the ring-cleavage product of gentisate. The enzyme can also act on a number of maleylpyruvate derivatives, such as (2E)-2-methyl-4,6-dioxohept-2-enedioate and (2E)-3-methyl-4,6-dioxohept-2-enedioate. Activated by Mn2+. May be identical to EC 3.7.1.5, acylpyruvate hydrolase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Hopper, D.J., Chapman, P.J. and Dagley, S. The enzymic degradation of alkyl-substituted gentisates, maleates and malates. Biochem. J. 122 (1971) 29–40. [PMID: 5124802] |
| 2. |
Bayly, R.C., Chapman, P.J., Dagley, S. and Di Berardino, D. Purification and some properties of maleylpyruvate hydrolase and fumarylpyruvate hydrolase from Pseudomonas alcaligenes. J. Bacteriol. 143 (1980) 70–77. [PMID: 7400101] |
| 3. |
Liu, K., Liu, T.T. and Zhou, N.Y. HbzF catalyzes direct hydrolysis of maleylpyruvate in the gentisate pathway of Pseudomonas alcaligenes NCIMB 9867. Appl. Environ. Microbiol. 79 (2013) 1044–1047. [DOI] [PMID: 23204427] |
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| [EC 3.7.1.23 created 2016] |
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