EC |
3.7.1.3 |
Accepted name: |
kynureninase |
Reaction: |
L-kynurenine + H2O = anthranilate + L-alanine |
|
For diagram of tryptophan catabolism, click here |
Systematic name: |
L-kynurenine hydrolase |
Comments: |
A pyridoxal-phosphate protein. Also acts on 3′-hydroxy-L-kynurenine and some other (3-arylcarbonyl)-alanines. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9024-78-6 |
References: |
1. |
Jakoby, W.B. and Bonner, D.M. Kynureninase from Neurospora: purification and properties. J. Biol. Chem. 205 (1953) 699–707. [PMID: 13129248] |
2. |
Jakoby, W.B. and Bonner, D.M. Kynureninase from Neurospora: interactions of enzyme with substrates, coenzyme and amines. J. Biol. Chem. 205 (1953) 709–715. [PMID: 13129249] |
3. |
Knox, W.E. The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency. Biochem. J. 53 (1953) 379–385. [PMID: 13032082] |
4. |
Wiss, O. and Weber, F. Die Reindarstellung der Kynureninase. Hoppe-Seyler's Z. Physiol. Chem. 304 (1956) 232–240. |
|
[EC 3.7.1.3 created 1965] |
|
|
|
|