ExplorEnz: EC 3.8.1.11

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3.8.1.11

Accepted name:

2-haloacid dehalogenase (configuration-retaining)

Reaction:

(1) (S)-2-haloacid + H₂O = (S)-2-hydroxyacid + halide
(2) (R)-2-haloacid + H₂O = (R)-2-hydroxyacid + halide

Other name(s):

2-haloalkanoic acid dehalogenase; 2-haloalkanoid acid halidohydrolase; DL-2-haloacid dehalogenase; DL-DEXr

Systematic name:

(S)-2-haloacid dehalogenase (configuration-retaining)

Comments:

Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)]

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Weightman, A.J., Weightman, A.L. and Slater, J.H. Stereospecificity of 2-monochloropropionate dehalogenation by the two dehalogenases of Pseudomonas P3: evidence for two different dehalogenation mechanisms. J. Gen. Microbiol. 128 (1982) 1755–1762. [DOI] [PMID: 7142958]
2.	Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N. Bacterial 2-haloacid dehalogenases: Structures and catalytic properties. Pure Appl. Chem. 68 (1996) 2097–2103.

[EC 3.8.1.11 created 2003]