ExplorEnz: EC 3.8.2.2

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3.8.2.2

Accepted name:

diisopropyl-fluorophosphatase

Reaction:

diisopropyl fluorophosphate + H₂O = diisopropyl phosphate + fluoride

Other name(s):

DFPase; tabunase; somanase; organophosphorus acid anhydrolase; organophosphate acid anhydrase; OPA anhydrase (ambiguous); diisopropylphosphofluoridase; dialkylfluorophosphatase; diisopropyl phosphorofluoridate hydrolase; isopropylphosphorofluoridase; diisopropylfluorophosphonate dehalogenase

Systematic name:

diisopropyl-fluorophosphate fluorohydrolase

Comments:

Acts on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including ‘nerve gases’). Inhibited by chelating agents; requires divalent cations. Related to EC 3.1.8.1 aryldialkylphosphatase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9032-18-2

References:

1.	Augustinsson, K.-B. and Heimburger, G. Enzymatic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolysing dimethyl-amido-ethoxy-phosphoryl cyanide (Tabun). Acta Chem. Scand. 8 (1954) 753–761. [DOI]
2.	Augustinsson, K.-B. and Heimburger, G. Enzymatic hydrolysis of organophosphorus compounds. II. Analysis of reaction products in experiments with Tabun and some properties of blood plasma tabunase. Acta Chem. Scand. 8 (1954) 762–767. [DOI]
3.	Augustinsson, K.-B. and Heimburger, G. Enzymatic hydrolysis of organophosphorus compounds. IV. Specificity studies. Acta Chem. Scand. 8 (1954) 1533–1541. [DOI]
4.	Cohen, J.A. and Warringa, M.G.P.J. Purification and properties of dialkylfluorophosphatase. Biochim. Biophys. Acta 26 (1957) 29–39. [DOI] [PMID: 13479457]
5.	Mounter, L.A. Enzymic hydrolysis of organophosphorus compounds. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd edn, vol. 4, Academic Press, New York, 1960, pp. 541–550.
6.	Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Ed.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989.

[EC 3.8.2.2 created 1961 as EC 3.8.2.1, transferred 1992 to EC 3.1.8.2, reinstated 2023 as EC 3.8.2.1]