| EC |
4.1.1.107 |
| Accepted name: |
3,4-dihydroxyphenylacetaldehyde synthase |
| Reaction: |
L-dopa + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 |
| Glossary: |
L-dopa = 3,4-dihydroxyphenylalanine |
| Other name(s): |
DHPAA synthase |
| Systematic name: |
L-dopa carboxy-lyase (oxidative-deaminating) |
| Comments: |
A pyridoxal 5′-phosphate protein. The enzyme, isolated from the mosquito Aedes aegypti, catalyses the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC 4.1.1.28, aromatic-L-amino-acid decarboxylase). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with α-methyl-L-dopa. |
| References: |
| 1. |
Vavricka, C., Han, Q., Huang, Y., Erickson, S.M., Harich, K., Christensen, B.M. and Li, J. From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects. PLoS One 6:e16124 (2011). [PMID: 21283636] |
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| [EC 4.1.1.107 created 2017] |
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