The Enzyme Database

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Accepted name: ferulate hydratase/lyase
Reaction: ferulate + H2O = vanillin + acetate (overall reaction)
(1a) ferulate + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoate
(1b) 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoate = vanillin + acetate
Glossary: ferulate = 4-hydroxy-3-methoxycinnamate
vanillin = 4-hydroxy-3-methoxybenzaldehyde
Other name(s): vanillin synthase; VpVan; VAN; ferulate aldolase
Systematic name: ferulate acetate-lyase (vanillin-forming)
Comments: The enzyme is located in the chloroplasts of vanilla pods of the orchid Vanilla planifolia. It also converts ferulic acid 4-O-β-D-glucopyranoside to vanillin 4-O-β-D-glucopyranoside.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Gallage, N.J., Hansen, E.H., Kannangara, R., Olsen, C.E., Motawia, M.S., Jørgensen, K., Holme, I., Hebelstrup, K., Grisoni, M. and Møller, B.L. Vanillin formation from ferulic acid in Vanilla planifolia is catalysed by a single enzyme. Nat. Commun. 5:4037 (2014). [DOI] [PMID: 24941968]
2.  Kundu, A. Vanillin biosynthetic pathways in plants. Planta 245 (2017) 1069–1078. [DOI] [PMID: 28357540]
3.  Gallage, N.J., Jørgensen, K., Janfelt, C., Nielsen, A.JZ., Naake, T., Dunski, E., Dalsten, L., Grisoni, M. and Møller, B.L. The intracellular localization of the vanillin biosynthetic machinery in pods of Vanilla planifolia. Plant Cell Physiol. 59 (2018) 304–318. [DOI] [PMID: 29186560]
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