ExplorEnz: EC 4.1.2.66

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4.1.2.66

Accepted name:

4-coumarate hydratase/lyase

Reaction:

4-coumarate + H₂O = 4-hydroxybenzaldehyde + acetate (overall reaction)
(1a) 4-coumarate + H₂O = 3-hydroxy-3-(4-hydroxyphenyl)propanoate
(1b) 3-hydroxy-3-(4-hydroxyphenyl)propanoate = 4-hydroxybenzaldehyde + acetate

Glossary:

4-coumarate = (2E)-3-(4-hydroxyphenyl)acrylate = (2E)-3-(4-hydroxyphenyl)prop-2-enoate

Other name(s):

4-hydroxybenzaldehyde synthase; 4HBS

Systematic name:

4-coumarate acetate-lyase (4-hydroxybenzaldehyde-forming)

Comments:

The enzyme has been purified from vanilla pods of the orchid Vanilla planifolia. It is highly specific for 4-coumarate. Similar compounds such as cinnamate, caffeate, sinapate and o-coumarate are not substrates.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Podstolski, A., Havkin-Frenkel, D., Malinowski, J., Blount, J.W., Kourteva, G. and Dixon, R.A. Unusual 4-hydroxybenzaldehyde synthase activity from tissue cultures of the vanilla orchid Vanilla planifolia. Phytochemistry 61 (2002) 611–620. [DOI] [PMID: 12423881]

[EC 4.1.2.66 created 2024]