ExplorEnz: EC 4.1.3.45

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4.1.3.45

Accepted name:

3-hydroxybenzoate synthase

Reaction:

chorismate = 3-hydroxybenzoate + pyruvate

For diagram of shikimate and chorismate biosynthesis, click here

Glossary:

chorismate = (3R,4R)-3-[(1-carboxyethenyl)oxy]-4-hydroxycyclohexa-1,5-diene-1-carboxylate

Other name(s):

chorismatase/3-hydroxybenzoate synthase; hyg5 (gene name); bra8 (gene name); XanB2

Systematic name:

chorismate pyruvate-lyase (3-hydroxybenzoate-forming)

Comments:

The enzyme, found in several bacterial species is involved in biosynthesis of secondary products. The enzyme from the bacterium Xanthomonas campestris pv. campestris also has the activity of EC 4.1.3.40, chorismate lyase [3].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Andexer, J.N., Kendrew, S.G., Nur-e-Alam, M., Lazos, O., Foster, T.A., Zimmermann, A.S., Warneck, T.D., Suthar, D., Coates, N.J., Koehn, F.E., Skotnicki, J.S., Carter, G.T., Gregory, M.A., Martin, C.J., Moss, S.J., Leadlay, P.F. and Wilkinson, B. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate. Proc. Natl. Acad. Sci. USA 108 (2011) 4776–4781. [DOI] [PMID: 21383123]
2.	Jiang, Y., Wang, H., Lu, C., Ding, Y., Li, Y. and Shen, Y. Identification and characterization of the cuevaene A biosynthetic gene cluster in Streptomyces sp. LZ35. ChemBioChem 14 (2013) 1468–1475. [DOI] [PMID: 23824670]
3.	Zhou, L., Wang, J.Y., Wang, J., Poplawsky, A., Lin, S., Zhu, B., Chang, C., Zhou, T., Zhang, L.H. and He, Y.W. The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways. Mol. Microbiol. 87 (2013) 80–93. [DOI] [PMID: 23113660]

[EC 4.1.3.45 created 2013]