The Enzyme Database

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Accepted name: 3′-dehydrocarminate deglycosidase
Reaction: 3′-dehydrocarminate = 1,5-anhydro-D-erythro-hex-1-en-3-ulose + kermesate
For diagram of carminate catabolism, click here
Glossary: carminate = 7-(β-D-glucopyranosyl)-3,5,6,8-tetrahydroxy-1-methyl-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate
kermesate = 3,5,6,8-tetrahydroxy-1-methyl-9,10-dioxo-9,10-dihydroanthracene-2-carboxylate
1,5-anhydro-D-erythro-hex-1-en-3-ulose = (2R,3R)-3,5-dihydroxy-2-(hydroxymethyl)-2,3-dihydropyran-4-one
Other name(s): carBC (gene names)
Systematic name: 3′-dehydrocarminate lyase (kermesate-forming)
Comments: Requires Mg2+. This enzyme, isolated from the bacterium Microbacterium 5-2b, participates in a carminate degradation pathway. Following the activity of EC, C-glycoside oxidase, it cleaves the C—C bond in 3′-dehydrocarminate. The sugar moiety is released lacking a hydroxyl at position 1, and containing a double bond between C-1 and C-2. The enzyme shows weak activity with other 3′-dehydro-C-glucosides.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Mori, T., Kumano, T., He, H., Watanabe, S., Senda, M., Moriya, T., Adachi, N., Hori, S., Terashita, Y., Kawasaki, M., Hashimoto, Y., Awakawa, T., Senda, T., Abe, I. and Kobayashi, M. C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes. Nat. Commun. 12:6294 (2021). [DOI] [PMID: 34728636]
[EC created 2023]

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