| EC |
4.1.99.3 |
| Accepted name: |
deoxyribodipyrimidine photo-lyase |
| Reaction: |
cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) |
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For diagram of reaction, click here |
| Other name(s): |
photoreactivating enzyme; DNA photolyase; DNA-photoreactivating enzyme; DNA cyclobutane dipyrimidine photolyase; DNA photolyase; deoxyribonucleic photolyase; deoxyribodipyrimidine photolyase; photolyase; PRE; PhrB photolyase; deoxyribonucleic cyclobutane dipyrimidine photolyase; phr A photolyase; dipyrimidine photolyase (photosensitive); deoxyribonucleate pyrimidine dimer lyase (photosensitive) |
| Systematic name: |
deoxyribocyclobutadipyrimidine pyrimidine-lyase |
| Comments: |
A flavoprotein (FAD), containing a second chromophore group. The enzyme catalyses the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37290-70-3 |
| References: |
| 1. |
Eker, A.P.M. and Fichtinger-Schepman, A.M.J. Studies on a DNA photoreactivating enzyme from Streptomyces griseus. II. Purification of the enzyme. Biochim. Biophys. Acta 378 (1975) 54–63. [DOI] [PMID: 804322] |
| 2. |
Sancar, G.B., Smith, F.W., Reid, R., Payne, G., Levy, M. and Sancar, A. Action mechanism of Escherichia coli DNA photolyase. I. Formation of the enzyme-substrate complex. J. Biol. Chem. 262 (1987) 478–485. [PMID: 3539939] |
| 3. |
Setlow, J.K. and Bollum, F.J. The minimum size of the substrate for yeast photoreactivating enzyme. Biochim. Biophys. Acta 157 (1968) 233–237. [DOI] [PMID: 5649902] |
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| [EC 4.1.99.3 created 1972] |
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