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Your query returned 1 entry. 
Printable version
| EC | 4.2.1.114 | ||
| Accepted name: | methanogen homoaconitase | ||
| Reaction: | (R)-2-hydroxybutane-1,2,4-tricarboxylate = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate (overall reaction) (1a) (R)-2-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O (1b) (Z)-but-1-ene-1,2,4-tricarboxylate + H2O = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate |
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| For diagram of the 2-aminoadipate pathway of L-lysine synthesis, click here | |||
| Glossary: | cis-homoaconitate = (Z)-but-1-ene-1,2,4-tricarboxylate (R)-homocitrate = (R)-2-hydroxybutane-1,2,4-tricarboxylate homoisocitrate = (–)-threo-homoisocitrate = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate |
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| Other name(s): | methanogen HACN | ||
| Systematic name: | (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate-forming] | ||
| Comments: | This enzyme catalyses several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea. Requires a [4Fe-4S] cluster for activity. In contrast to EC 4.2.1.36, homoaconitate hydratase, this enzyme can catalyse both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate. In addition to cis-homoaconitate, the enzyme can also catalyse the hydration of the physiological substrates dihomoaconitate and trihomoaconitate as well as the non-physiological substrate tetrahomoaconitate. cis-Aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme. | ||
| Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB | ||
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