| EC |
4.2.1.128 |
| Accepted name: |
lupan-3β,20-diol synthase |
| Reaction: |
lupan-3β,20-diol = (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O |
|
For diagram of lupeol and lupan-3β,20-diol biosynthesis, click here |
| Other name(s): |
LUP1 (gene name) |
| Systematic name: |
(3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (lupan-3β,20-diol-forming) |
| Comments: |
The reaction occurs in the reverse direction. The recombinant enzyme from Arabidopsis thaliana gives a 1:1 mixture of lupeol and lupan-3β,20-diol with small amounts of β-amyrin, germanicol, taraxasterol and ψ-taraxasterol. See EC 5.4.99.41 (lupeol synthase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Segura, M.J., Meyer, M.M. and Matsuda, S.P. Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol. Org. Lett. 2 (2000) 2257–2259. [DOI] [PMID: 10930257] |
| 2. |
Kushiro, T., Hoshino, M., Tsutsumi, T., Kawai, K., Shiro, M., Shibuya, M. and Ebizuka, Y. Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization. Org. Lett. 8 (2006) 5589–5592. [DOI] [PMID: 17107079] |
|
| [EC 4.2.1.128 created 2011] |
| |
|
| |
|
Printable version