| EC |
4.2.1.129 |
| Accepted name: |
squalene—hopanol cyclase |
| Reaction: |
hopan-22-ol = squalene + H2O |
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For diagram of hopene and tetrahymanol biosynthesis, click here |
| Other name(s): |
squalene—hopene cyclase (ambiguous) |
| Systematic name: |
hopan-22-ol hydro-lyase |
| Comments: |
The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Hoshino, T., Nakano, S., Kondo, T., Sato, T. and Miyoshi, A. Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring. Org Biomol Chem 2 (2004) 1456–1470. [DOI] [PMID: 15136801] |
| 2. |
Sato, T., Kouda, M. and Hoshino, T. Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. Biosci. Biotechnol. Biochem. 68 (2004) 728–738. [PMID: 15056909] |
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| [EC 4.2.1.129 created 2011] |
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