ExplorEnz: EC 4.2.1.130

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4.2.1.130

Accepted name:

D-lactate dehydratase

Reaction:

(R)-lactate = 2-oxopropanal + H₂O

Glossary:

methylglyoxal = 2-oxopropanal
(R)-lactate = D-lactate

Other name(s):

glyoxylase III; GLO3

Systematic name:

(R)-lactate hydro-lyase

Comments:

The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Hasim, S., Hussin, N.A., Alomar, F., Bidasee, K.R., Nickerson, K.W. and Wilson, M.A. A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans. J. Biol. Chem. 289 (2014) 1662–1674. [DOI] [PMID: 24302734]
2.	Zhao, Q., Su, Y., Wang, Z., Chen, C., Wu, T. and Huang, Y. Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe. BMC Evol Biol 14:86 (2014). [DOI] [PMID: 24758716]

[EC 4.2.1.130 created 2011]