| EC |
4.2.1.143 |
| Accepted name: |
versicolorin B synthase |
| Reaction: |
versiconal = versicolorin B + H2O |
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For diagram of aflatoxin biosynthesis (part 2), click here |
| Glossary: |
versiconal = (2S,3S)-2,4,6,8-tetrahydroxy-3-(2-hydroxyethyl)anthra[2,3-b]furan-5,10-dione
versicolorin B = (3aR,12bS)-8,10,12-trihydroxy-1,2,3a,12b-tetrahydroanthra[2,3-b]furo[3,2-d]furan-6,11-dione
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| Other name(s): |
versiconal cyclase; VBS |
| Systematic name: |
versiconal hydro-lyase (versicolorin-B-forming) |
| Comments: |
Isolated from the aflatoxin-producing mold Aspergillus parasiticus. Involved in aflatoxin biosynthesis. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Lin, B.K. and Anderson, J.A. Purification and properties of versiconal cyclase from Aspergillus parasiticus. Arch. Biochem. Biophys. 293 (1992) 67–70. [DOI] [PMID: 1731640] |
| 2. |
McGuire, S.M., Silva, J.C., Casillas, E.G. and Townsend, C.A. Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis of the stereodifferentiating cyclization in aflatoxin biosynthesis essential to DNA interaction. Biochemistry 35 (1996) 11470–11486. [DOI] [PMID: 8784203] |
| 3. |
Silva, J.C., Minto, R.E., Barry, C.E., 3rd, Holland, K.A. and Townsend, C.A. Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Expansion of the aflatoxin b1 biosynthetic gene cluster. J. Biol. Chem. 271 (1996) 13600–13608. [DOI] [PMID: 8662689] |
| 4. |
Silva, J.C. and Townsend, C.A. Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus parasiticus. A key enzyme in the aflatoxin B1 biosynthetic pathway. J. Biol. Chem. 272 (1997) 804–813. [DOI] [PMID: 8995367] |
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| [EC 4.2.1.143 created 2013] |
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