| EC |
4.2.1.147 |
| Accepted name: |
5,6,7,8-tetrahydromethanopterin hydro-lyase |
| Reaction: |
5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O |
| Other name(s): |
formaldehyde-activating enzyme |
| Systematic name: |
5,6,7,8-tetrahydromethanopterin hydro-lyase (formaldehyde-adding, tetrahydromethanopterin-forming) |
| Comments: |
Found in methylotrophic bacteria and methanogenic archaea. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Vorholt, J.A., Marx, C.J., Lidstrom, M.E. and Thauer, R.K. Novel formaldehyde-activating enzyme in Methylobacterium extorquens AM1 required for growth on methanol. J. Bacteriol. 182 (2000) 6645–6650. [DOI] [PMID: 11073907] |
| 2. |
Acharya, P., Goenrich, M., Hagemeier, C.H., Demmer, U., Vorholt, J.A., Thauer, R.K. and Ermler, U. How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1. J. Biol. Chem. 280 (2005) 13712–13719. [DOI] [PMID: 15632161] |
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| [EC 4.2.1.147 created 2014] |
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