ExplorEnz: EC 4.2.1.153

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4.2.1.153

Accepted name:

3-methylfumaryl-CoA hydratase

Reaction:

(S)-citramalyl-CoA = 3-methylfumaryl-CoA + H₂O

For diagram of the 3-hydroxypropanoate cycle, click here

Glossary:

(S)-citramalyl-CoA = (3S)-3-carboxy-3-hydroxybutanoyl-CoA
3-methylfumaryl-CoA = (E)-3-carboxybut-2-enoyl-CoA

Other name(s):

Meh; mesaconyl-C₄-CoA hydratase; mesaconyl-coenzyme A hydratase (ambiguous)

Systematic name:

(S)-citramalyl-CoA hydro-lyase (3-methylfumaryl-CoA-forming)

Comments:

The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Zarzycki, J., Brecht, V., Muller, M. and Fuchs, G. Identifying the missing steps of the autotrophic 3-hydroxypropionate CO₂ fixation cycle in Chloroflexus aurantiacus. Proc. Natl. Acad. Sci. USA 106 (2009) 21317–21322. [DOI] [PMID: 19955419]

[EC 4.2.1.153 created 2014]