ExplorEnz: EC 4.2.1.182

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4.2.1.182

Accepted name:

phosphomevalonate dehydratase

Reaction:

(R)-5-phosphomevalonate = (2E)-3-methyl-5-phosphooxypent-2-enoate + H₂O

Glossary:

(2E)-3-methyl-5-phosphooxypent-2-enoate = trans-anhydromevalonate 5-phosphate

Systematic name:

(R)-5-phosphomevalonate hydro-lyase

Comments:

The enzyme catalyses a step in an archaeal prenyl diphosphate biosynthesis pathway. It belongs to the aconitase X family, and contains a [4Fe-4S] cluster.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Hayakawa, H., Motoyama, K., Sobue, F., Ito, T., Kawaide, H., Yoshimura, T. and Hemmi, H. Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate. Proc. Natl. Acad. Sci. USA 115 (2018) 10034–10039. [DOI] [PMID: 30224495]
2.	Yoshida, R., Yoshimura, T. and Hemmi, H. Reconstruction of the "archaeal" mevalonate pathway from the methanogenic archaeon Methanosarcina mazei in Escherichia coli cells. Appl. Environ. Microbiol. 86:e02889-19 (2020). [DOI] [PMID: 31924615]
3.	Komeyama, M., Kanno, K., Mino, H., Yasuno, Y., Shinada, T., Ito, T. and Hemmi, H. A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway. Front Microbiol. 14:1150353 (2023). [DOI] [PMID: 36992929]

[EC 4.2.1.182 created 2023]