| EC |
4.2.1.22 |
| Accepted name: |
cystathionine β-synthase |
| Reaction: |
L-serine + L-homocysteine = L-cystathionine + H2O |
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For diagram of L-Methionine biosynthesis, click here |
| Other name(s): |
serine sulfhydrase; β-thionase; methylcysteine synthase; cysteine synthase (incorrect); serine sulfhydrylase; L-serine hydro-lyase (adding homocysteine) |
| Systematic name: |
L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) |
| Comments: |
A pyridoxal-phosphate protein. A multifunctional enzyme: catalyses β-replacement reactions between L-serine, L-cysteine, cysteine thioethers, or some other β-substituted α-L-amino acids, and a variety of mercaptans. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9023-99-8 |
| References: |
| 1. |
Braunstein, A.E., Goryachinkova, E.V., Tolosa, E.A., Willhardt, I.H. and Yefremova, L.L. Specificity and some other properties of liver serine sulphhydrase: evidence for its identity with cystathionine-synthase. Biochim. Biophys. Acta. 242 (1971) 247–260. [DOI] [PMID: 5121611] |
| 2. |
Nakagawa, H. and Kimura, H. Purification and properties of cystathionine synthetase synthetase from rat liver: separation of cystathionine synthetase from serine dehydratase. Biochem. Biophys. Res. Commun. 32 (1968) 209–214. [PMID: 5672136] |
| 3. |
Schlossmann, K., Brüggemann, J. and Lynen, F. Biosynthese des Cysteins. I. Nachweis und Isolierung der Serinsulfhydrase aus Bäckerhefe. Biochem. Z. 336 (1962) 258–273. [PMID: 13991884] |
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| [EC 4.2.1.22 created 1961 (EC 4.2.1.21 created 1961, incorporated 1964, EC 4.2.1.23 created 1961, incorporated 1972)] |
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