| EC |
4.2.1.28 |
| Accepted name: |
propanediol dehydratase |
| Reaction: |
propane-1,2-diol = propanal + H2O |
| Other name(s): |
meso-2,3-butanediol dehydrase; diol dehydratase; DL-1,2-propanediol hydro-lyase; diol dehydrase; adenosylcobalamin-dependent diol dehydratase; propanediol dehydrase; coenzyme B12-dependent diol dehydrase; 1,2-propanediol dehydratase; dioldehydratase; propane-1,2-diol hydro-lyase; RiDD |
| Systematic name: |
propane-1,2-diol hydro-lyase (propanal-forming) |
| Comments: |
Two different forms of the enzyme have been described. One form requires a cobamide cofactor, while the other is a glycyl radical enzyme. The cobamide-dependent enzyme has been shown to also dehydrate ethylene glycol to acetaldehyde. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9026-90-8 |
| References: |
| 1. |
Abeles, R.H. and Lee, H.A., Jr. An intramolecular oxidation-reduction requiring a cobamide coenzyme. J. Biol. Chem. 236 (1961) 2347–2350. [PMID: 13680987] |
| 2. |
Lee, H.A. and Abeles, R.H. Purification and properties of dioldehydrase, and enzyme requiring a cobamide coenzyme. J. Biol. Chem. 238 (1963) 2367–2373. [PMID: 13929077] |
| 3. |
Forage, R.G. and Foster, M.A. Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases. J. Bacteriol. 149 (1982) 413–419. [PMID: 7035429] |
| 4. |
LaMattina, J.W., Keul, N.D., Reitzer, P., Kapoor, S., Galzerani, F., Koch, D.J., Gouvea, I.E. and Lanzilotta, W.N. 1,2-Propanediol dehydration in Roseburia inulinivorans: structural basis for substrate and enantiomer selectivity. J. Biol. Chem. 291 (2016) 15515–15526. [DOI] [PMID: 27252380] |
|
| [EC 4.2.1.28 created 1965] |
| |
|
| |
|
Printable version