| EC |
4.2.1.45 |
| Accepted name: |
CDP-glucose 4,6-dehydratase |
| Reaction: |
CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O |
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For diagram of CDP-abequose, CDP-ascarylose, CDP-paratose and CDP-tyrelose biosynthesis, click here |
| Other name(s): |
cytidine diphosphoglucose oxidoreductase; CDP-glucose 4,6-hydro-lyase |
| Systematic name: |
CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming) |
| Comments: |
Requires bound NAD+. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37259-55-5 |
| References: |
| 1. |
Hey, A.E. and Elbein, A.D. Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase. J. Biol. Chem. 241 (1966) 5473–5478. [PMID: 4380946] |
| 2. |
Matsuhashi, S., Matsuhashi, M., Brown, J.G. and Strominger, J.L. Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3. Cytidine diphosphate D-glucose oxidoreductase. J. Biol. Chem. 241 (1966) 4283–4287. [PMID: 4288651] |
| 3. |
Melo, A., Elliott, H. and Glaser, L. The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase. J. Biol. Chem. 243 (1968) 1467–1474. [PMID: 4869560] |
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| [EC 4.2.1.45 created 1972] |
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