| EC |
4.2.1.49 |
| Accepted name: |
urocanate hydratase |
| Reaction: |
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H2O |
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| Glossary: |
urocanate = (E)-3-(imidazol-4-yl)propenoate |
| Other name(s): |
urocanase; 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase |
| Systematic name: |
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming) |
| Comments: |
Contains tightly bound NAD+. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9014-58-8 |
| References: |
| 1. |
Rétey, J. The urocanase story: a novel role of NAD+ as electrophile. Arch. Biochem. Biophys. 314 (1994) 1–16. [DOI] [PMID: 7944380] |
| 2. |
Hassall, H. and Greenberg, D.M. Urocanase (beef liver). Methods Enzymol. 17B (1971) 84–88. |
| 3. |
Kaminskas, E., Kimhi, Y. and Magasanik, B. Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway. J. Biol. Chem. 245 (1970) 3536–3544. [PMID: 4990470] |
| 4. |
Swaine, D. The effect of substrate analogues on the activity of cat liver urocanase. Biochim. Biophys. Acta 178 (1969) 609–618. [DOI] [PMID: 5784906] |
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| [EC 4.2.1.49 created 1972, modified 2001] |
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