EC |
4.2.1.51 |
Accepted name: |
prephenate dehydratase |
Reaction: |
prephenate = phenylpyruvate + H2O + CO2 |
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For diagram of phenylalanine and tyrosine biosynthesis, click here |
Other name(s): |
prephenate hydro-lyase (decarboxylating) |
Systematic name: |
prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming) |
Comments: |
This enzyme in the enteric bacteria also possesses chorismate mutase (EC 5.4.99.5) activity, and converts chorismate into prephenate. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9044-88-6 |
References: |
1. |
Cerutti, P. and Guroff, G. Enzymatic formation of phenylpyruvic acid in Pseudomonas sp. (ATCC 11299A) and its regulation. J. Biol. Chem. 240 (1965) 3034–3048. [PMID: 14342329] |
2. |
Cotton, R.G.H. and Gibson, F. The biosynthesis of phenylalanine and tyrosine; enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase. Biochim. Biophys. Acta 100 (1965) 76–88. [DOI] [PMID: 14323651] |
3. |
Schmidt, J.C. and Zalkin, H. Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium. Biochemistry 8 (1969) 174–181. [PMID: 4887851] |
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[EC 4.2.1.51 created 1972] |
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