| EC |
4.2.1.75 |
| Accepted name: |
uroporphyrinogen-III synthase |
| Reaction: |
hydroxymethylbilane = uroporphyrinogen III + H2O |
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For diagram of the early stages of porphyrin biosynthesis, click here and for mechanism of reaction, click here |
| Other name(s): |
porphobilinogenase; uroporphyrinogen isomerase; uroporphyrinogen III cosynthase; URO-synthase; hydroxymethylbilane hydro-lyase (cyclizing) |
| Systematic name: |
hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming) |
| Comments: |
In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen III from porphobilinogen. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37340-55-9 |
| References: |
| 1. |
Battersby, A.R., Fookes, C.J.R., Matcham, G.W.J. and McDonald, E. Biosynthesis of the pigments of life: formation of the macrocycle. Nature 285 (1980) 17–21. [PMID: 6769048] |
| 2. |
Tsai, S.-F., Bishop, D.F. and Desnick, R.J. Purification and properties of uroporphyrinogen III synthase from human erythrocytes. J. Biol. Chem. 262 (1987) 1268–1273. [PMID: 3805019] |
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| [EC 4.2.1.75 created 1982] |
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