| EC |
4.2.1.9 |
| Accepted name: |
dihydroxy-acid dehydratase |
| Reaction: |
2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O |
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For diagram of isoleucine and valine biosynthesis, click here |
| Other name(s): |
acetohydroxyacid dehydratase; α,β-dihydroxyacid dehydratase; 2,3-dihydroxyisovalerate dehydratase; α,β-dihydroxyisovalerate dehydratase; dihydroxy acid dehydrase; DHAD; 2,3-dihydroxy-acid hydro-lyase |
| Systematic name: |
2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming) |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9024-32-2 |
| References: |
| 1. |
Kanamori, M. and Wixom, R.L. Studies in valine biosynthesis. V. Characteristics of the purified dihydroxyacid dehydratase from spinach leaves. J. Biol. Chem. 238 (1963) 998–1005. [PMID: 13962154] |
| 2. |
Myers, J.W. Dihydroxy acid dehydrase: an enzyme involved in the biosynthesis of isoleucine and valine. J. Biol. Chem. 236 (1961) 1414–1418. [PMID: 13727223] |
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| [EC 4.2.1.9 created 1961] |
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