| EC |
4.2.3.115 |
| Accepted name: |
α-terpinene synthase |
| Reaction: |
geranyl diphosphate = α-terpinene + diphosphate |
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For diagram of menthane monoterpenoid biosynthesis, click here |
| Glossary: |
α-terpinene = 1-isopropyl-4-methylcyclohexa-1,3-diene |
| Systematic name: |
geranyl-diphosphate diphosphate-lyase (cyclizing, α-terpinene-forming) |
| Comments: |
The enzyme has been characterized from Dysphania ambrosioides (American wormseed). Requires Mg2+. Mn2+ is less effective. The enzyme will also use (3R)-linalyl diphosphate. The reaction involves a 1,2-hydride shift. The 1-pro-S hydrogen of geranyl diphosphate is lost. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Poulose, A.J. and Croteau, R. γ-Terpinene synthetase: a key enzyme in the biosynthesis of aromatic monoterpenes. Arch. Biochem. Biophys. 191 (1978) 400–411. [DOI] [PMID: 736574] |
| 2. |
LaFever, R.E. and Croteau, R. Hydride shifts in the biosynthesis of the p-menthane monoterpenes α-terpinene, γ-terpinene, and β-phellandrene. Arch. Biochem. Biophys. 301 (1993) 361–366. [DOI] [PMID: 8460944] |
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| [EC 4.2.3.115 created 2012] |
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