EC |
4.2.3.125 |
Accepted name: |
α-muurolene synthase |
Reaction: |
(2E,6E)-farnesyl diphosphate = α-muurolene + diphosphate |
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For diagram of cadinane sesquiterpenoid biosynthesis, click here |
Other name(s): |
Cop3 |
Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, α-muurolene-forming) |
Comments: |
The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and γ-muurolene, see EC 4.2.3.23, germacrene-A synthase and EC 4.2.3.126, γ-muurolene synthase.
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Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
References: |
1. |
Agger, S., Lopez-Gallego, F. and Schmidt-Dannert, C. Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus. Mol. Microbiol. 72 (2009) 1181–1195. [DOI] [PMID: 19400802] |
2. |
Lopez-Gallego, F., Wawrzyn, G.T. and Schmidt-Dannert, C. Selectivity of fungal sesquiterpene synthases: role of the active site’s H-1α loop in catalysis. Appl. Environ. Microbiol. 76 (2010) 7723–7733. [DOI] [PMID: 20889795] |
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[EC 4.2.3.125 created 2012] |
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