ExplorEnz: EC 4.2.3.133

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4.2.3.133

Accepted name:

α-copaene synthase

Reaction:

(2E,6E)-farnesyl diphosphate = (-)-α-copaene + diphosphate

For diagram of cadinane sesquiterpenoid biosynthesis, click here

Glossary:

(-)-α-copaene = (1R,2S,6S,7S,8S)-1,3-dimethyl-8-(propan-2-yl)tricyclo[4.4.0.0^2,7]dec-3-ene
For diagram of the structures of α-copaene and β-copaene, click here

Systematic name:

(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, α-copaene-forming)

Comments:

Isolated from Helianthus annuus (sunflower). The enzyme also produces β-caryophyllene, δ-cadinene and traces of other sesquiterpenoids. See EC 4.2.3.13 (+)-δ-cadinene synthase, EC 4.2.3.57 (-)-β-caryophyllene synthase.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Gopfert, J.C., Macnevin, G., Ro, D.K. and Spring, O. Identification, functional characterization and developmental regulation of sesquiterpene synthases from sunflower capitate glandular trichomes. BMC Plant Biol. 9:86 (2009). [DOI] [PMID: 19580670]
2.	Xie, X., Kirby, J. and Keasling, J.D. Functional characterization of four sesquiterpene synthases from Ricinus communis (castor bean). Phytochemistry 78 (2012) 20–28. [DOI] [PMID: 22459969]

[EC 4.2.3.133 created 2012]