| EC |
4.2.3.148 |
| Accepted name: |
cembrene C synthase |
| Reaction: |
geranylgeranyl diphosphate = cembrene C + diphosphate |
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For diagram of cembrene and related diterpenoids, click here |
| Glossary: |
cembrene C = (1E,5E,9E)-1,5,9-trimethyl-12-(propan-2-ylidene)cyclotetradeca-1,5,9-triene |
| Other name(s): |
DtcycA (gene name) |
| Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase (cembrene-C-forming) |
| Comments: |
Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This bifunctional enzyme also produces (R)-nephthenol. See EC 4.2.3.149, nephthenol synthase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Meguro, A., Tomita, T., Nishiyama, M. and Kuzuyama, T. Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton. ChemBioChem 14 (2013) 316–321. [DOI] [PMID: 23386483] |
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| [EC 4.2.3.148 created 2014] |
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