| EC |
4.2.3.149 |
| Accepted name: |
nephthenol synthase |
| Reaction: |
geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate |
|
For diagram of cembrene and related diterpenoids, click here |
| Glossary: |
(R)-nephthenol = 2-[(1R,3E,7E,11E)-4,8,12-trimethyltetradeca-3,7,11-trien-1-yl]propan-2-ol |
| Other name(s): |
DtcycA (gene name); DtcycB (gene name) |
| Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase [(R)-nephthenol-forming] |
| Comments: |
Requires Mg2+. Two isozymes with this activity were isolated from the bacterium Streptomyces sp. SANK 60404. The enzyme encoded by the DtcycA gene also produces cembrene C (see EC 4.2.3.148, cembrene C synthase), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Meguro, A., Tomita, T., Nishiyama, M. and Kuzuyama, T. Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton. ChemBioChem 14 (2013) 316–321. [DOI] [PMID: 23386483] |
|
| [EC 4.2.3.149 created 2014] |
| |
|
| |
|
Printable version