| EC |
4.2.3.158 |
| Accepted name: |
(–)-spiroviolene synthase |
| Reaction: |
geranylgeranyl diphosphate = (–)-spiroviolene + diphosphate |
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For diagram of biosynthesis of fusicoccane diterpenoids, click here |
| Glossary: |
(–)-spiroviolene = (2R,3a′S,3b′R,5S,6a′R)-2,4′,4′,5,6a′-pentamethyl-2′,3′,3a′,3b′,4′,5′,6′,6a′-octahydrospiro[cyclopentane-1,1′-cyclopenta[a]pentalene] |
| Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, (–)-spiroviolene-forming] |
| Comments: |
The enzyme, which forms the diterpene (–)-spiroviolene, has been characterized from the bacterium Streptomyces violens. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Rabe, P., Rinkel, J., Dolja, E., Schmitz, T., Nubbemeyer, B., Luu, T.H. and Dickschat, J.S. Mechanistic investigations of two bacterial diterpene cyclases: spiroviolene synthase and tsukubadiene synthase. Angew. Chem. Int. Ed. Engl. 56 (2017) 2776–2779. [DOI] [PMID: 28146322] |
| 2. |
Xu, H. and Dickschat, J.S. Revision of the cyclisation mechanism for the diterpene spiroviolene and investigations of Its mass spectrometric fragmentation. Chembiochem 22 (2021) 850–854. [DOI] [PMID: 33084237] |
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| [EC 4.2.3.158 created 2017] |
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