| EC |
4.2.3.159 |
| Accepted name: |
tsukubadiene synthase |
| Reaction: |
geranylgeranyl diphosphate = tsukubadiene + diphosphate |
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For diagram of biosynthesis of fusicoccane diterpenoids, click here |
| Glossary: |
tsukubadiene = (1S,3aS,5Z,7aS,10aR,11Z)-1,5,8,8,10a-pentamethyl-2,3,3a,4,7,7a,8,9,10,10a-decahydro-1H-dicyclopenta[a,d][9]annulene |
| Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, tsukubadiene-forming) |
| Comments: |
The synthesis of the diterpene tsukubadiene has been shown to occur in the Actinobacterium Streptomyces tsukubaensis. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Yamada, Y., Arima, S., Nagamitsu, T., Johmoto, K., Uekusa, H., Eguchi, T., Shin-ya, K., Cane, D.E. and Ikeda, H. Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host. J. Antibiot. (Tokyo) 68 (2015) 385–394. [DOI] [PMID: 25605043] |
| 2. |
Rabe, P., Rinkel, J., Dolja, E., Schmitz, T., Nubbemeyer, B., Luu, T.H. and Dickschat, J.S. Mechanistic investigations of two bacterial diterpene cyclases: spiroviolene synthase and tsukubadiene synthase. Angew. Chem. Int. Ed. Engl. 56 (2017) 2776–2779. [DOI] [PMID: 28146322] |
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| [EC 4.2.3.159 created 2017] |
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